Éliane Meurs, directrice de recherche à l’Institut Pasteur, est chef d’unité.
She has a solid expertise on signaling pathways leading to induction of IFN and on the mechanism of action of the dsRNA-dependent protein kinase PKR. She was originally responsible for the cloning of this kinase which opened the door to its study, worldwide. She was also pionneer in demonstrating that PKR modulates signaling pathways involved in inflammation independently of its enzymatic activity. PKR is now emerging as an important kinase related to stress. Their current studies focus on the mechanisms by which PKR acts either as an antiviral or a pro-stress agent in HCV infection. They also examine the role of PKR in stress-associated neurodegenerative diseases such as Alzheimer disease. They investigate the role of PKR in the modulation of several signalling pathways, linked to deregulation of lipid metabolism, insulin resistance, autophagy and they are developping screening of chemical compound libraries to generate novel PKR inhibitors for clinical purpose.